Anti-Tumor Effect of a Local Delivery System; Hydroxyapatite-Alginate Beads of Paclitaxel
نویسندگان
چکیده
This study was conducted to clarify direct antitumor effect of this local delivery system of paclitaxel. Rat’s breast cancer cell line (CRL-1666) and Fischer 344 rat were used. When subcutaneous tumor (injected subcutaneously) size reached 10 mm in diameter, animals in the local treatment group were administered locally at dose of 5 mg/kg of paclitaxel-loaded HAp-alginate beads. Sham operation was performed in the control group. Tumor burden and body weights of the animals were checked at 3, 7, 10 days after treatment. Tumor burden at 10 days was a mean of 8.1 g and 17.2 g for the local treatment group and untreated group, respectively. Although local delivery of paclitaxel-loaded HAp-alginate beads did not inhibit the proliferation of subcutaneous tumor, proliferation time was significantly delayed in treated rats. Our studies revealed that local delivery of paclitaxel-loaded HAp-alginate beads delayed the time to progression of subcutaneous breast cancer in rats.
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